Vitamin D supplementation during pregnancy in Greek population
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Mitera Hospital, Athens, Greece
Obstetrician – Gynecologist, Athens, Greece
Department of Midwifery, University of West Attica, Athens, Greece
Publication date: 2023-10-24
Eur J Midwifery 2023;7(Supplement 1):A85
Vitamin D deficiency or insufficiency is thought to be common among pregnant women. Recently, a special attention has been paid to gestational hypovitaminosis D in relation to pregnancy outcomes. There is little information on vitamin D intake in pregnancy and lactation and few studies on clinical outcomes. Vitamin D supplementation during pregnancy has been suggested as an intervention to protect against adverse gestational outcomes.

The aim of this study is to determine the necessary vitamin D supplementation in a cohort of Greek pregnant women. The main goals of this study are: a) to analyze and correlate data of pregnant women with different therapeutic protocols for vitamin D supplementation during pregnancy and relation to vitamin D insufficiency or deficiency of the newborn.

Material and Methods:
All pregnant women from a private clinic of a maternity hospital in Athens were randomized and included in the study. A single blind randomized design was used in order to define three groups of pregnant women who received different vitamin D3 supplementation after the 12th week of pregnancy (Group A<8400 IU per week; Group B<12800 IU per week; Group C>16800 IU per week). Maternal vitamin D3(OH-VitD3) levels were recorded on the 3rd month of gestation and the 1st postpartum day. Newborns’ vitamin levels (OH-VitD3) were measured on the 3rd day of their life.

In total 192 pregnant women and 194 newborns were involved in the study. Newborns absorb Vitamin D3 from their mother. There is a significant proportion of pregnant women who have vitamin D deficiency or insufficiency both on the 3rd month of gestation (91%) and on the delivery date (80%). Only 15% of newborns demonstrated low vitamin D levels at birth. Vitamin D supplementation with a dose of 16800 iu weekly from the 3rd month of pregnancy seems to have a significant effect on fetal vitamin D levels, resulting to no infant with vitamin D deficiency (less than 15ng/ml). In our survey there is no indication of adverse effect of Vitamin D on newborn’s weight or premature labor. Premature labor is not associated with higher maternal levels of vitamin D.

Vitamin D supplementation during pregnancy is safe and provides an efficient therapeutic modality to prevent maternal and neonatal vitamin D deficiency or insufficiency.

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