BACKGROUND:
Hyperemesis Gravidarum (HG) is a complex, multisystem condition characterised by severe and prolonged nausea and vomiting in pregnancy. It has substantial impacts on physical and mental wellbeing. Although multidisciplinary care is recommended, there is limited evidence on its real-world effectiveness, particularly within midwifery-led models. The IRIS clinic is a novel, midwifery-led multidisciplinary day-case service providing integrated support for women with HG.

OBJECTIVES:
To describe the baseline symptom burden and well-being of individuals attending the IRIS clinic and assess changes following intervention. To examine the impact of coordinated, midwifery-led care on physical and emotional recovery.

METHODS:
A prospective observational study was conducted with 73 clinic attendees. At Time 1, participants completed the Pregnancy Symptoms Inventory (PSI), PUQE scale (nausea/vomiting), WHO-5 (wellbeing), and SF-12 (health-related quality of life, broken down into Physical Component Summary (PCS) and Mental Component Summary (MCS). Fifty-one participants completed follow-up questionnaires at Time 2. Paired-samples t-tests were used to assess changes over time.

RESULTS:
At baseline, 94.1% had moderate or severe PUQE scores (M = 10.56), and 95.9% had poor wellbeing scores, indicated by a score of below 50 (M = 18.87). Quality of life scores were well below average (PCS: M = 35.01; MCS: M = 40.37). At follow-up, significant improvements were seen in nausea and vomiting (p < .001, d = 0.75), wellbeing (p < .001, d = –1.24), and physical functioning (p = .016, d = 0.51). Symptoms such as drowsiness, excessive saliva, and isolation also improved. However, mental functioning did not significantly change (MCS p = .81).

CONCLUSIONS:
Midwifery-led multidisciplinary care was associated with reduced symptom burden and improved physical and emotional wellbeing. Persistent psychological symptoms highlight the need for integrated perinatal mental health support.

KEY MESSAGE:
Midwifery-led multidisciplinary clinics can provide effective, holistic care for HG, improving outcomes while identifying gaps needing targeted mental health intervention. Poster session 2 (Group A)