CONFERENCE PROCEEDING
The incidence of risk factors for developing breast cancer
 
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1
Breast Imagining Department, Mitera Hospital, Athens, Greece
 
2
Midwifery Department, University of West Attica, Greece
 
 
Publication date: 2023-10-24
 
 
Corresponding author
Sofia Dimou   

Breast Imagining Department, Mitera Hospital, Athens, Greece
 
 
Eur J Midwifery 2023;7(Supplement 1):A94
 
KEYWORDS
ABSTRACT
Introduction:
Breast cancer is the most common cancer in women worldwide, with an incidence 1,7 million in 2012. Breast cancer is about 25%, among women population and the fifth leading cause of mortality1,2. The aim of this review is the recognition of the breast cancer risk factors, for the early detection, diagnosis and the effective treatment strategies.

Material and Methods:
A systemic search was performed on research studies on breast cancer risk factors in PubMed and Embase databases, published between 2000 and 2022. This review considered retrospective studies, systemic reviews and meta-analysis, in English language. On research has been included studies with risk factors such as age, sex, ethnicity, use of oral contraceptive pills and hormonal replacement therapy, chest radiation, reproductive factors, personal or family history of breast disease, genetic pre – disposition and lifestyle such as high body mass index, exposure to tobacco and alcohol consumption, which have been associated with an increased risk for the development of breast cancer. A total number of 250 studies were retrieved, as potentially relevant. 165 studies were irrelevant, and 85 studies were eligible for further assessment. Of 53 studies that were identified, 10 were excluded, because were not relevant to chosen risk factors. 43 studies were relevant and examined in further detailed. Studies were analyzed and extracted using PRISMA flowchart.

Results:
According to the included studies the age, sex, ethnicity, use of oral contraceptive pills and hormonal replacement therapy, chest radiation, reproductive factors, personal or family history of breast disease and genetic pre – disposition were significantly associated with an increased risk of developing breast cancer3-30. Also, lifestyle risk factors as obesity31-34, alcohol consumption35 and limited physical activity are strongly36-39 associated with breast cancer. However, the relationship between smoking and breast cancer risk remains controversial40-44.

Conclusions:
Breast cancer develops through a multistep process and influenced by genetic, environmental and lifestyle factors. Targeted prevention strategies against these risk factors and personalized risk assessment for breast cancer screening should be taken.

REFERENCES (44)
1.
International Agency for Research on Cancer, 2016
 
2.
World Health Organization. Breast cancer. Published July 12, 2023. https://www.who.int/news-room/...
 
3.
Shah R, Rosso K, Nathanson SD. Pathogenesis, prevention, diagnosis and treatment of breast cancer. World J Clin Oncol. 2014;5(3):283-298. doi:10.5306/wjco.v5.i3.283
 
4.
McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ. 2000;321(7261):624-628. doi:10.1136/bmj.321.7261.624
 
5.
Bland KI, Beenken SW, Copeland III EM. The Breast. In: Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Pollock RE. Schwartz’s Principles of Surgery. 8th ed. New York: McGraw-Hill; 2005:453-500
 
6.
Hasson-Ohayon I, Goldzweig G, Braun M, Galinsky D. Women with advanced breast cancer and their spouses: diversity of support and psychological distress. Psychooncology. 2010;19(11):1195-1204. doi:10.1002/pon.1678
 
7.
Gierisch JM, Coeytaux RR, Urrutia RP, et al. Oral contraceptive use and risk of breast, cervical, colorectal, and endometrial cancers: a systematic review. Cancer Epidemiol Biomarkers Prev. 2013;22(11):1931-1943. doi:10.1158/1055-9965.EPI-13-0298
 
8.
Hunter DJ, Colditz GA, Hankinson SE, et al. Oral contraceptive use and breast cancer: a prospective study of young women. Cancer Epidemiol Biomarkers Prev. 2010;19(10):2496-2502. doi:10.1158/1055-9965.EPI-10-0747
 
9.
Hilakivi-Clarke L. Maternal exposure to diethylstilbestrol during pregnancy and increased breast cancer risk in daughters. Breast Cancer Res. 2014;16(2):208. doi:10.1186/bcr3649
 
10.
Vinogradova Y, Coupland C, Hippisley-Cox J. Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the QResearch and CPRD databases. BMJ. 2020;371:m3873. doi:10.1136/bmj.m3873
 
11.
Barańska A, Błaszczuk A, Kanadys W, Malm M, Drop K, Polz-Dacewicz M. Oral Contraceptive Use and Breast Cancer Risk Assessment: A Systematic Review and Meta-Analysis of Case-Control Studies, 2009-2020. Cancers (Basel). 2021;13(22):5654. doi:10.3390/cancers13225654
 
12.
Henderson TO, Amsterdam A, Bhatia S, et al. Systematic review: surveillance for breast cancer in women treated with chest radiation for childhood, adolescent, or young adult cancer. Ann Intern Med. 2010;152(7):444-W154. doi:10.7326/0003-4819-152-7-201004060-00009
 
13.
Oeffinger KC, Mertens AC, Sklar CA, et al. Chronic health conditions in adult survivors of childhood cancer. N Engl J Med. 2006;355(15):1572-1582. doi:10.1056/NEJMsa060185
 
14.
Turcotte LM, Liu Q, Yasui Y, et al. Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015. JAMA. 2017;317(8):814-824. doi:10.1001/jama.2017.0693
 
15.
Horn J, Vatten LJ. Reproductive and hormonal risk factors of breast cancer: a historical perspective. Int J Womens Health. 2017;9:265-272. doi:10.2147/IJWH.S129017
 
16.
McPherson K, Steel CM, Dixon JM. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ. 2000;321(7261):624-628. doi:10.1136/bmj.321.7261.624
 
17.
Pike MC, Pearce CL, Wu AH. Prevention of cancers of the breast, endometrium and ovary. Oncogene. 2004;23(38):6379-6391. doi:10.1038/sj.onc.1207899
 
18.
Clavel-Chapelon F; E3N-EPIC Group. Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer. Results from a large cohort of French women. Br J Cancer. 2002;86(5):723-727. doi:10.1038/sj.bjc.6600124
 
19.
González-Jiménez E, García PA, Aguilar MJ, Padilla CA, Álvarez J. Breastfeeding and the prevention of breast cancer: a retrospective review of clinical histories. J Clin Nurs. 2014;23(17-18):2397-2403. doi:10.1111/jocn.12368
 
20.
Ip S, Chung M, Raman G, Trikalinos TA, Lau J. A summary of the Agency for Healthcare Research and Quality's evidence report on breastfeeding in developed countries. Breastfeed Med. 2009;4 Suppl 1:S17-S30. doi:10.1089/bfm.2009.0050
 
21.
Lipworth L, Bailey LR, Trichopoulos D. History of breast-feeding in relation to breast cancer risk: a review of the epidemiologic literature. J Natl Cancer Inst. 2000;92(4):302-312. doi:10.1093/jnci/92.4.302
 
22.
Britt K, Ashworth A, Smalley M. Pregnancy and the risk of breast cancer. Endocr Relat Cancer. 2007;14(4):907-933. doi:10.1677/ERC-07-0137
 
23.
Collaborative Group on Hormonal Factors in Breast Cancer. Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol. 2012;13(11):1141-1151. doi:10.1016/S1470-2045(12)70425-4
 
24.
Singletary SE. Rating the risk factors for breast cancer. Ann Surg. 2003;237(4):474-482. doi:10.1097/01.SLA.0000059969.64262.87
 
25.
Domchek S, Weber BL. Inherited genetic factors and breast cancer. In: Harris JR, Lippman ME, Morrow M, Osborne CK, ed. Diseases of the Breast, 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2004:276-313.
 
26.
Brewer HR, Jones ME, Schoemaker MJ, Ashworth A, Swerdlow AJ. Family history and risk of breast cancer: an analysis accounting for family structure. Breast Cancer Res Treat. 2017;165(1):193-200. doi:10.1007/s10549-017-4325-2
 
27.
Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies [published correction appears in Am J Hum Genet. 2003 Sep;73(3):709]. Am J Hum Genet. 2003;72(5):1117-1130. doi:10.1086/375033
 
28.
Scott CL, Jenkins MA, Southey MC, et al. Average age-specific cumulative risk of breast cancer according to type and site of germline mutations in BRCA1 and BRCA2 estimated from multiple-case breast cancer families attending Australian family cancer clinics. Hum Genet. 2003;112(5-6):542-551. doi:10.1007/s00439-003-0908-6
 
29.
Balmaña J, Díez O, Rubio IT, Cardoso F, ESMO Guidelines Working Group. BRCA in breast cancer: ESMO Clinical Practice Guidelines. Ann Oncol. 2011;22 Suppl 6:vi31-vi34. doi:10.1093/annonc/mdr373
 
30.
Paluch-Shimon S, Cardoso F, Sessa C, et al. Prevention and screening in BRCA mutation carriers and other breast/ovarian hereditary cancer syndromes: ESMO Clinical Practice Guidelines for cancer prevention and screening [published correction appears in Ann Oncol. 2017 Jul 1;28(suppl_4):iv167-iv168]. Ann Oncol. 2016;27(suppl 5):v103-v110. doi:10.1093/annonc/mdw327
 
31.
Alegre MM, Knowles MH, Robison RA, O'Neill KL. Mechanics behind breast cancer prevention - focus on obesity, exercise and dietary fat. Asian Pac J Cancer Prev. 2013;14(4):2207-2212. doi:10.7314/apjcp.2013.14.4.2207
 
32.
Vrieling A, Buck K, Kaaks R, Chang-Claude J. Adult weight gain in relation to breast cancer risk by estrogen and progesterone receptor status: a meta-analysis. Breast Cancer Res Treat. 2010;123(3):641-649. doi:10.1007/s10549-010-1116-4
 
33.
Eliassen AH, Colditz GA, Rosner B, Willett WC, Hankinson SE. Adult weight change and risk of postmenopausal breast cancer. JAMA. 2006;296(2):193-201. doi:10.1001/jama.296.2.193
 
34.
van den Brandt PA, Spiegelman D, Yaun SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol. 2000;152(6):514-527. doi:10.1093/aje/152.6.514
 
35.
Scoccianti C, Lauby-Secretan B, Bello PY, Chajes V, Romieu I. Female breast cancer and alcohol consumption: a review of the literature. Am J Prev Med. 2014;46(3 Suppl 1):S16-S25. doi:10.1016/j.amepre.2013.10.031
 
36.
Eliassen AH, Hankinson SE, Rosner B, Holmes MD, Willett WC. Physical activity and risk of breast cancer among postmenopausal women. Arch Intern Med. 2010;170(19):1758-1764. doi:10.1001/archinternmed.2010.363
 
37.
Garber CE, Blissmer B, Deschenes MR, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334-1359. doi:10.1249/MSS.0b013e318213fefb
 
38.
Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat. 2013;137(3):869-882. doi:10.1007/s10549-012-2396-7
 
39.
Lynch BM, Neilson HK, Friedenreich CM. Physical activity and breast cancer prevention. Recent Results Cancer Res. 2011;186:13-42. doi:10.1007/978-3-642-04231-7_2
 
40.
National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US); 2014
 
41.
Reynolds P. Smoking and breast cancer. J Mammary Gland Biol Neoplasia. 2013;18(1):15-23. doi:10.1007/s10911-012-9269-x
 
42.
Glantz SA, Johnson KC. The surgeon general report on smoking and health 50 years later: breast cancer and the cost of increasing caution. Cancer Epidemiol Biomarkers Prev. 2014;23(1):37-46. doi:10.1158/1055-9965.EPI-13-1081
 
43.
Catsburg C, Miller AB, Rohan TE. Active cigarette smoking and risk of breast cancer. Int J Cancer. 2015;136(9):2204-2209. doi:10.1002/ijc.29266
 
44.
Kispert S, McHowat J. Recent insights into cigarette smoking as a lifestyle risk factor for breast cancer. Breast Cancer (Dove Med Press). 2017;9:127-132. doi:10.2147/BCTT.S129746
 
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